ISSN 0929-8673
Foreword by the Editors
Atta-ur-Rahman,; J. Hoekstra, William
1-1
Editorial [Hot Topic: Novel Physiological and Pharmacological Avenues in the Mechanism of Gastrointestinal Integrity, Protection and Ulcer Healing (Guest Editors: Thomas Brzozowski)]
Brzozowski, Thomas
2-3
The Mechanisms of Gastric Mucosal Injury: Focus on Microvascular Endothelium as a Key Target
S. Tarnawski, A.; Ahluwalia, A.; K. Jones, M.
4-15
Molecular Mechanisms of Epithelial Regeneration and Neovascularization During Healing of Gastric and Esophageal Ulcers
S. Tarnawski, A.; Ahluwalia, A.
16-27
Recent Advances in Gut Nutrient Chemosensing
A. Nguyen, C.; Akiba, Y.; D. Kaunitz, J.
28-34
Brainstem Neuropeptides and Vagal Protection of the Gastric Mucosal Against Injury: Role of Prostaglandins, Nitric Oxide and Calcitonin-Gene Related Peptide in Capsaicin Afferents
Tache, Y.
35-42
Gas Mediators Involved in Modulating Duodenal HCO3- Secretion
Takeuchi, K.; Aihara, E.; Kimura, M.; Dogishi, K.; Hara, T.; Hayashi, S.
43-54
Novel Concept in the Mechanism of Injury and Protection of Gastric Mucosa: Role of Renin-Angiotensin System and Active Metabolites of Angiotensin
Brzozowski, T.; Ptak-Belowska, A.; Kwiecien, S.; Krzysiek-Maczka, G.; Strzalka, M.; Drozdowicz, D.; Pajdo, R.; Olszanecki, R.; Korbut, R.; J. Konturek, S.; W. Pawlik, W.
55-62
Effects of Cigarette Smoke and its Active Components on Ulcer Formation and Healing in the Gastrointestinal Mucosa
Zhang, L.; W. Ren, J.; C.M. Wong, C.; K.K. Wu, W.; X. Ren, S.; Shen, J.; L.Y. Chan, R.; H. Cho, C.
63-69
Therapeutic Potential of Carbon Monoxide (CO) for Intestinal Inflammation
Naito, Y.; Uchiyama, K.; Takagi, T.; Yoshikawa, T.
70-76
Small Intestinal Injury Caused by NSAIDs/Aspirin: Finding New from Old
Arakawa, T.; Watanabe, T.; Tanigawa, T.; Tominaga, K.; Otani, K.; Nadatani, Y.; Fujiwara, Y.
77-81
Management of NSAID/Aspirin-Induced Small Intestinal Damage by GI-Sparing NSAIDs, Anti-Ulcer Drugs and Food Constituents
Satoh, H.; Takeuchi, K.
82-89
Critical Role of Hypoxia Sensor - HIF-1α in VEGF Gene Activation. Implications for Angiogenesis and Tissue Injury Healing
Ahluwalia, A.; S. Tarnawski, A.
90-97
The ECL Cell: Relay Station for Gastric Integrity
-M. Zhao, C.; Chen, D.
98-108
Nutraceuticals for Protection and Healing of Gastrointestinal Mucosa
Romano, M.; Vitaglione, P.; Sellitto, S.; D'Argenio, G.
109-117
Protective and Therapeutic Effects of Ghrelin in the Gut
Warzecha, Z.; Dembinski, A.
118-125
Focus on Ulcerative Colitis: Stable Gastric Pentadecapeptide BPC 157
Sikiric, P.; Seiwerth, S.; Rucman, R.; Turkovic, B.; S. Rokotov, D.; Brcic, L.; Sever, M.; Klicek, R.; Radic, B.; Drmic, D.; Ilic, S.; Kolenc, D.; Stambolija, V.; Zoricic, Z.; Vrcic, H.; Sebecic, B.
126-132
MicroRNAs and Chronic Inflammation Contribution to Gastrointestinal Integrity
Ptak-Belowska, A.; Targosz, A.; Brzozowski, T.
133-136
The Role of Methylglyoxal-Modified Proteins in Gastric Ulcer Healing
Takagi, T.; Naito, Y.; Oya-Ito, T.; Yoshikawa, T.
137-144
The Inhibition of Cell Proliferation Using Silencing of N-Cadherin Gene by siRNA Process in Human Melanoma Cell Lines
Ciolczyk-Wierzbicka, D.; Gil, D.; Laidler, P.
145-151
Dihydro-alkoxyl-benzyl-oxopyrimidine Derivatives (DABOs) As Non-Nucleoside Reverse Transcriptase Inhibitors: An Update Review (2001-2011)
Yang, Shiqiong; Chen, Fen-Er; De Clercq, Erik
152-162
Targeting Mitogen-Activated Protein Kinase Phosphatase-1 (MKP-1): Structure-Based Design of MKP-1 Inhibitors and Upregulators
R. Doddareddy, M.; Rawling, T.; J. Ammit, A.
163-173
Recent Progresses on AI-2 Bacterial Quorum Sensing Inhibitors
Zhu, Peng; Li, Minyong
174-186
Non-Invasive Biomarkers of Lung Inflammation in Smoking Subjects
Malerba, M.; Montuschi, P.
187-196
Nonviral Approach for Targeted Nucleic Acid Delivery
Jafari, M.; Soltani, M.; Naahidi, S.; N. Karunaratne, D.; Chen, P.
197-208
Exploring Pharmacological Significance of Chalcone Scaffold: A Review
K. Sahu, N.; S. Balbhadra, S.; Choudhary, J.; V. Kohli, D.
209-225
Specific Noncovalent Interactions at Protein-Ligand Interface: Implications for Rational Drug Design
Zhou, P.; Huang, J.; Tian, F.
226-238
Recent Researches in Triazole Compounds as Medicinal Drugs
-H. Zhou, C.; Wang, Y.
239-280
Gyroxin and Its Biological Activity: Effects on CNS Basement Membranes and Endothelium and Protease-Activated Receptors
A.A. da Silva, J.; Spencer, P.; A. Camillo, M.; M.F. de Lima, V.
281-291
Neuroprotective Properties of Nicotine
Sieber, M.
292-297
The Pharmacological Control of Neuronal Excitability in the Retinal Spreading Depression Model of Migraine
Wiedemann, M.; Lyhs, B.; -P. Bartels, J.; Sieber, M.
298-302
Editorial [Hot Topic: Relevance of Integration at the Membrane Level of Receptor-Receptor Interactions in Neurodegenerative Diseases and Drug Addiction (Guest Editor: Sergio Tanganelli)]
Tanganelli, Sergio
303-303
Relevance of Dopamine D2/Neurotensin NTS1 and NMDA/Neurotensin NTS1 Receptor Interaction in Psychiatric and Neurodegenerative Disorders
Tanganelli, S.; Antonelli, T.; C. Tomasini, M.; Beggiato, S.; Fuxe, K.; Ferraro, L.
304-316
The Importance of the Adenosine A2A Receptor-Dopamine D2 Receptor Interaction in Drug Addiction
Filip, M.; Zaniewska, M.; Frankowska, M.; Wydra, K.; Fuxe, K.
317-355
GPCR Heteromers and their Allosteric Receptor-Receptor Interactions
Fuxe, K.; O. Borroto-Escuela, D.; Marcellino, D.; Romero-Fernandez, W.; Frankowska, M.; Guidolin, D.; Filip, M.; Ferraro, L.; Woods, A.S.; Tarakanov, A.; Ciruela, F.; F. Agnati, L.; Tanganelli, S.
356-363
DNA Interstrand Cross-Linking Agents and their Chemotherapeutic Potential
Brulikova, L.; Hlavac, J.; Hradil, P.
364-385
Nitric Oxide: State of the Art in Drug Design
Serafim, R.A.M.; Primi, M.C.; Trossini, G.H.G.; Ferreira, E.I.
386-405
New Perspectives in Antiplatelet Therapy
Tello-Montoliu, A.; Jover, E.; Rivera, J.; Valdes, M.; Angiolillo, D.J.; Marin, F.
406-427
Emerging Targets for the Pharmacological Treatment of Depression: Focus on Melatonergic System
Catena-Dell'Osso, Mario; Marazziti, Donatella; Rotella, Francesco; Bellantuono, Cesario
428-437
Novel and Emerging Drugs for Systemic Lupus Erythematosus: Mechanism of Action and Therapeutic Activity
Robak, E.; Robak, T.
438-453
Transforming Growth Factor β Signaling Perturbation in the Loeys-Dietz Syndrome
Pezzini, A.; Del Zotto, E.; Giossi, A.; Volonghi, I.; Costa, P.; Padovani, A.
454-460
Cancer Regulator MicroRNA: Potential Relevance in Diagnosis, Prognosis and Treatment of Cancer
Fiorucci, G.; V. Chiantore, M.; Mangino, G.; A. Percario, Z.; Affabris, E.; Romeo, G.
461-474
Multi-Targeted Histone Deacetylase Inhibitors in Cancer Therapy
Ai, T.; Cui, H.; Chen, L.
475-487
Developments in Chemical Approaches to Treat Tuberculosis in the Last Decade
P. Tripathi, R.; S. Bisht, S.; Ajay, A.; Sharma, A.; Misra, M.; Pd. Gupt, M.
488-517
Potential Therapeutic Targeting of Platelet-Mediated Cellular Interactions in Atherosclerosis and Inflammation
Nagy Jr., B.; Miszti-Blasius, K.; Kerenyi, A.; J. Clemetson, K.; Kappelmayer, J.
518-531
n-3 Fatty Acid-Derived Lipid Mediators in the Brain: New Weapons Against Oxidative Stress and Inflammation
A. Farooqui, A.
532-543
Structure-Based Design in the GPCR Target Space
Kontoyianni, M.; Liu, Z.
544-556
Advancements in Z-DNA: Development of Inducers and Stabilizers for B to Z Transition
Yang, L.; Wang, S.; Tian, T.; Zhou, X.
557-568
A Review on Biological Activities and Chemical Synthesis of Hydrazide Derivatives
Narang, R.; Narasimhan, B.; Sharma, S.
569-612
2-Hydroxy-1-oxo-1,2-dihydroisoquinoline-3-carboxylic Acid with Inbuilt β-NHydroxy-γ-keto-acid Pharmacophore as HCV NS5B Polymerase Inhibitors
R. Deore, R.; S. Chen, G.; -S. Chen, C.; -T. Chang, P.; -H. Chuang, M.; -R. Chern, T.; -C. Wang, H.; -W. Chern, J.
613-624
Editorial [Hot Topic: Ion Channels and Cancers (Guest Editor: Robert Kiss)]
Kiss, Robert
625-626
Cardiotonic Steroids-Mediated Targeting of the Na+/K+-ATPase to Combat Chemoresistant Cancers
Mijatovic, T.; Dufrasne, F.; Kiss, R.
627-646
Is the Multifunctional Na+/H+ Exchanger Isoform 1 a Potential Therapeutic Target in Cancer?
Stock, C.; Ludwig, F.T.; Schwab, A.
647-660
Targeting the Voltage-Dependent K+ Channels Kv1.3 and Kv1.5 as Tumor Biomarkers for Cancer Detection and Prevention
Felipe, A.; Bielanska, J.; Comes, N.; Vallejo, A.; Roig, S.; Ramon y Cajal, S.; Condom, E.; Hernandez-Losa, J.; Ferreres, J.C.
661-674
Approaches Targeting KV10.1 Open a Novel Window for Cancer Diagnosis and Therapy
Pardo, L.A.; Gomez-Varela, D.; Major, F.; Sansuk, K.; Leurs, R.; Downie, B.R.; Tietze, L.F.; Stuhmer, W.
675-682
Targeting Ion Channels in Leukemias: A New Challenge for Treatment
Arcangeli, A.; Pillozzi, S.; Becchetti, A.
683-696
Targeting SKCa Channels in Cancer: Potential New Therapeutic Approaches
Girault, A.; Haelters, J.-P.; Potier-Cartereau, M.; Chantome, A.; Jaffres, P.-A.; Bougnoux, P.; Joulin, V.; Vandier, C.
697-713
Mitochondrial VDAC1: Function in Cell Life and Death and a Target for Cancer Therapy
Shoshan-Barmatz, V.; Golan, M.
714-735
Structure-Function Relationships of Iodinated Contrast Media and Risk of Nephrotoxicity
Stratta, P.; Quaglia, M.; Airoldi, A.; Aime, S.
736-743
Nanotechnology Based Diagnostic and Therapeutic Strategies for Neuroscience with Special Emphasis on Ischemic Stroke
Nair, S.B.; Dileep, A.; Rajanikant, G.K.
744-756
Polysaccharide-K (PSK) in Cancer - Old Story, New Possibilities?
Sun, C.; Rosendahl, A.H.; Wang, X.D.; Wu, D.Q.; Andersson, R.
757-762
Synthesis and Antinociceptive Behaviors of New Methyl and Hydroxyl Derivatives of Phencyclidine
Ahmadi, A.; Kermani, M.; Naderi, N.; Hajikhani, R.; Rezaee, N.M.; Javadi, M.; Niknafs, B.N.
763-769
Ginsenoside Rg1 Attenuates Lipopolysaccharide-Induced Inflammatory Responses Via the Phospholipase C-γ1 Signaling Pathway in Murine BV-2 Microglial Cells
Zong, Y.; Ai, Q.-L.; Zhong, L.-M.; Dai, J.-N.; Yang, P.; He, Y.; Sun, J.; Ling, E.-A.; Lu, D.
770-779
Editorial [ Hot Topic-I: Applications of the Photodynamic Therapy to Cancer,Water- and Vector-Borne Diseases (Guest Editor: Luigi E. Xodo )]
E. Xodo, Luigi
780-780
Non Polymeric Nanoparticles for Photodynamic Therapy Applications: Recent Developments
Chouikrat, R.; Seve, A.; Vanderesse, R.; Benachour, H.; Barberi-Heyob, M.; Richeter, S.; Raehm, L.; Durand, J.-O.; Verelst, M.; Frochot, C.
781-792
Molecular Response to Hypericin-Induced Photodamage
Krammer, B.; Verwanger, T.
793-798
The Chlorophyll Catabolite Pheophorbide a as a Photosensitizer for the Photodynamic Therapy
E. Xodo, L.; Rapozzi, V.; Zacchigna, M.; Drioli, S.; Zorzet, S.
799-807
Porphyrin Photosensitised Processes in the Prevention and Treatment of Water- and Vector-Borne Diseases
Coppellotti, O.; Fabris, C.; Soncin, M.; Magaraggia, M.; Camerin, M.; Jori, G.; Guidolin, L.
808-819
Editorial [ Hot Topic-II: Zinc Metallo-Enzymes as Target for Drug Design (Guest Editor: Giuseppina De Simone )]
De Simone, Giuseppina
820-820
Carbonic Anhydrase IX as a Target for Designing Novel Anticancer Drugs
M. Monti, S.; T. Supuran, C.; De Simone, G.
821-830
Inhibition of Bacterial Carbonic Anhydrases and Zinc Proteases: From Orphan Targets to Innovative New Antibiotic Drugs
T. Supuran, C.
831-844
Structure Based Drug Design of Angiotensin-I Converting Enzyme Inhibitors
S. Anthony, C.; Masuyer, G.; D. Sturrock, E.; R. Acharya, K.
845-855
Glutamate Carboxypeptidase II in Diagnosis and Treatment of Neurologic Disorders and Prostate Cancer
Barinka, C.; Rojas, C.; Slusher, B.; Pomper, M.
856-870
Exploration of Chemical Space Based on 4-Anilinoquinazoline
Li, D.-D.; Hou, Y.-P.; Wang, W.; Zhu, H.-L.
871-892
Protein Degradation by the Ubiquitin-Proteasome Pathway and Organ Fibrosis
Fukasawa, H.; Fujigaki, Y.; Yamamoto, T.; Hishida, A.; Kitagawa, M.
893-900
Novel Biomarkers Assessing the Calcium Deposition in Coronary Artery Disease
Tousoulis, D.; Siasos, G.; Maniatis, K.; Oikonomou, E.; Vlasis, K.; G. Papavassiliou, A.; Stefanadis, C.
901-920
Modulation of Ascorbic Acid-Induced DNA Cleavage by Polyamide: Cleavage Manner, Kinetics and Mechanism
Li, C.; Duan, S.; Xu, J.; Qiao, R.; Xu, P.; Zhao, Y.
921-926
Novel Biotransformation Process of Podophyllotoxin to 4 -Sulfur-Substituted Podophyllum Derivates with Anti-Tumor Activity by Penicillium purpurogenum Y.J. Tang
Bai, J.-K.; Zhao, W.; Li, H.-M.; Tang, Y.-J.
927-936